Zhiyuan is currently a postdoctoral scientist working with Prof Tatjana Sauka-Spengler at the MRC Weatherall Institute of Molecular Medicine, University of Oxford. Her research focuses on studying embryonic development by using single-cell omics and CRISPR techniques.

After undergrad study in biological science at the Peking University, the top university in China, she graduated with the first ranking from the Honors Program. During her DPhil at the Wellcome Centre for Human Genetics and the MRC Weatherall Institute of Molecular Medicine, University of Oxford, she was co-supervised by Professor Ahmed Ahmed and Professor Christopher Yau. She studied nonsense-mediated decay in the pan-cancer genomes and single-cell transcriptomics of the origin of ovarian cancer.

Research interest: single cell, multi-omics, bioinformatics, development

Selected publications

Z. Hu, M. Artibani, A. Alsaadi, N. Wietek, M. Morotti, T. Shi, Z. Zhong, L. Santana Gonzalez, S. El-Sahhar, M. KaramiNejadRanjbar, G. Mallett, Y. Feng, K. Masuda, Y. Zheng, K. Chong, S. Damato, S. Dhar, L. Campo, R. Garruto Campanile, V. Rai, D. Maldonado-Perez, S. Jones, V. Cerundolo, T. Sauka-Spengler, C. Yau*, A. A. Ahmed*. The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells. Cancer Cell 37 (2), p226-242.E7 (2020). Paper Code

Z. Hu†, P. Cunnea†, Z. Zhong, H. Lu, O. Osagie, L. Campo, M. Artibani, K. Nixon, J. Ploski, L. Santana Gonzalez, A. Alsaadi, N. Wietek, S. Damato, S. Dhar, S. P. Blagden, C. Yau, J. Hester, A. Albukhari, E. O. Aboagye, C. Fotopoulou*, A. A. Ahmed*. The Oxford Classic links epithelial-mesenchymal transition to immunosuppression in poor prognosis ovarian cancers. Clinical Cancer Research 27(5):1570-1579 (2021). doi: 10.1158/1078-0432.CCR-20-2782. Paper Code

Z. Hu, C. Yau* and A. Ahmed*. A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay. Nature Communications 8, 15943 (2017). doi: 10.1038/ncomms15943. Paper Code R package

Y. Liu†, Z. Hu†, J. Cheng, P. Siejka-Zielińska, J. Chen, M. Inoue, A. A. Ahmed, C.-X. Song. Subtraction-free and bisulfite-free specific sequencing of 5-methylcytosine and its oxidized derivatives at base resolution. Nature Communications 12, Article number: 618 (2021). Paper Code

Preprint

Z. Hu, C. Yau* and A. Ahmed*. An interpretable meta-clustering framework for single-cell RNA-Seq data integration and evaluation. bioRxiv (2021). Paper R package CIDER

The full publication list is available at Google Scholar